Two Cases of Gram-Positive Sepsis Successfully Treated with Vancomycin in Combination with Imipenem or Cilastatin

Imipenem/cilastatin: rationale for a fixed combination.

Imipenem is renally metabolized to the stable open-lactam metabolite by a dipeptidase, dehydropeptidase I, located at the lumenal surface of the proximal tubular cells. In humans the degree of hydrolysis shows marked intersubject variability but minimal intrasubject variability. In healthy subjects the urinary recovery of unchanged imipenem ranged from 5.5% to 42.5% of the dose. Cilastatin inhi...

construction of vector fields with positive lyapunov exponents

in this thesis our aim is to construct vector field in r3 for which the corresponding one-dimensional maps have certain discontinuities. two kinds of vector fields are considered, the first the lorenz vector field, and the second originally introced here. the latter have chaotic behavior and motivate a class of one-parameter families of maps which have positive lyapunov exponents for an open in...

Bacteremia caused by Elizabethkingia meningoseptica in a mechanically ventilated patient successfully treated with imipenem-cilastatin and ciprofloxacin

Two Cases of Leprosy Successfully Treated

The case was one of the mixed variety; he had crooked fingers, a little thickening of the lobes of the ears in which leprosy bacilli were found, superficial anaesthesia of the legs almost up to the knees and of the forearm's and hands all round, and swelling of the ankles. General health?poor, almost emaciated, and unable to do any work. No family history of contact, but he had been in prolonge...

Pharmacokinetics of imipenem-cilastatin in neonates.

Imipenem and its renal dehydropeptidase I inhibitor, cilastatin, were coadministered intravenously in a 1:1 ratio to 30 newborns. Five infants each received single doses of 10, 15, or 20 mg/kg of both drugs. Concentrations in plasma were proportional to the administered dose, and cilastatin achieved consistently higher concentrations than did equivalent doses of imipenem because of its smaller ...